B6;129X1-Grin3a^tm1Nnk/J

Stock number: 029974
Product name: NR3A KO
Research areas: Developmental Biology Research, Neurobiology Research, Research Tools, Sensorineural Research

Description

 

These Grin3a (NR3A or GluN3A) knock-out mice exhibit locomotor deficits, increased sensitivity to pain, enhanced recognition and spatial memory, and more severe damage from ischemia. They are suitable for use in applications related to the study of neuronal dendritic spine development, synaptic plasticity, neuroprotection in stroke and neurodegenerative diseases.

Allele

Symbol: Grin3a^tm1Nnk
Name: targeted mutation 1, Nobuki Nakanishi
MGI accession ID: MGI:2387963
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: NR3A-
Marker symbol: Grin3a
Marker name: glutamate receptor ionotropic, NMDA3A
Marker synonyms: A830097C19Rik; chi-1; GluN3A; NMDAR3A; NMDAR-L; NR3; NR3A
Chromosome: 4
Strain of origin: 129X1/SvJ
Molecular note: The region encoding the N-terminal 118 amino acids (including the translation initation codon) was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals lacked gene expression as demonstrated by Northern and Western blot analysis of brain samples.