These NG2-Cre transgenic mice express Cre recombinase under control of the mouse Cspg4 (chondroitin sulfate proteoglycan 4) gene promoter. Cre activity is detected in renal vascular structures, including the glomeruli, in healthy mice. In fibrotic kidneys, Cre activity is detected in interstitial cells and vascular structures.
The Donating Investigator reports Cre activity is detected on rare occasions in gametes resulting in germline recombination, and recommends screening for recombination of floxed alleles in non-target tissues.
Hemizygotes are viable and fertile. Homozygous viability/fertility has not been tested (October 2017).
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

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NG2-cre transgenic mice express Cre recombinase in Cspg4 expressing pericytes. These mice may be useful for Cre-lox studies related to the role of Cspg4 expressing pericytes in cancer progression and fibrosis.

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Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.