The targeted Trem2 gene encodes a protein that is part of a receptor signaling complex with TYRO protein tyrosine kinase binding protein, and that activates macrophages and dendritic cells during immune responses. Loss-of-function variants of the TREM2 gene are associated with Alzheimer's Disease. These mice possess loxP sites on either side of exons 2 and 3 of the targeted gene.
The donating investigator reports that homozygotes are viable and fertile. As the mice are characterized, we will modify the strain description and add phenotype data.
When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2 and 3 deleted in the cre-expressing tissues.

Use of MICE only available to non-profit entities.

These floxed mutant mice possess loxP sites flanking exons 2 and 3 of the Trem2 gene. This strain may be useful for generating conditional mutations in applications related to Alzheimer's Disease.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.