CRISPR/cas9 endonuclease-mediated genome editing of the Nek1, NIMA (never in mitosis gene a)-related expressed kinase 1, gene was used to introduce a 10 nucleotide deletion in exon 2. The targeted Nek1 gene encodes a serine/threonine kinase involved in cell cycle, cilia regulation and axonal development. Mutations in this gene have been associated with short rib-polydactyly syndrome type II, polycystic kidney disease, and susceptibility to amyotrophic lateral sclerosis-24. Homozygous mice are viable and fertile. As the mice are characterized, we will modify the strain description and add phenotype data.

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This CRISPR/Cas9 generated mutant of the Nek1 gene carries a 10 nucleotide deletion in exon 2.

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