Exons 5 and 6 of the mouse Dusp8 (dual specificity phosphatase 8) gene have been replaced with a neomycin cassette to create a knockout allele. Absence of mRNA was confirmed in brain, heart, and lung by the donating laboratory. Homozygous mice are viable and fertile, and are protected from cardiac stress. They are mildly hypercontractile at baseline with a cardiac phenotype of concentric ventricular remodeling, which protects them from progressing towards heart failure in two surgery-induced disease models. Adult cardiac myocytes are thick and short. Animals have an increased baseline of Mapk3 (ERK1) and Mapk1 (ERK2) activity which alters the length-width growth dynamics of individual cardiac myocytes, further affecting contractility, ventricular remodeling, and disease susceptibility.

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These mice carry a targeted knockout of the mouse Dusp8 gene and are useful in studies of cardiac remodeling, contractility and disease susceptibility.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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