This strain has exon 5 deleted, which disrupts the reading frame and eliminates both the N-terminal EF-hand domain and the C-terminal mitochondrial membrane-bound transporter domain. These Slc25a13 null mice have no overt phenotypic abnormalities. Homozygotes are viable and fertile.
Working in C57BL/6J-derived ES cells, exon 5 was replaced with a loxP flanked neomycin selection cassette in the laboratory of Dr. Kenneth Johnson at The Jackson Laboratory. The founder was bred to C57BL/6J generating the C57BL/6J-Slc25a13
|Allele Name||targeted mutation 2.1, Kenneth R Johnson|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Slc25a13, solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13|
|Strain of Origin||C57BL/6J|
|Molecular Note||exon 5 was replaced by a loxP flanked neomycin resistance cassette to generate a null allele and subsequent breeding to a Cre-deleter strain excised the neomycin resistance cassette to yield this null allele|