These Slc25a13 null mice have no overt phenotypic abnormalities. Homozygotes are viable and fertile.
Kenneth Johnson, JAX
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Slc25a13 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 |
This strain has exon 5 deleted, which disrupts the reading frame and eliminates both the N-terminal EF-hand domain and the C-terminal mitochondrial membrane-bound transporter domain. These Slc25a13 null mice have no overt phenotypic abnormalities. Homozygotes are viable and fertile.
Working in C57BL/6J-derived ES cells, exon 5 was replaced with a loxP flanked neomycin selection cassette in the laboratory of Dr. Kenneth Johnson at The Jackson Laboratory. The founder was bred to C57BL/6J generating the C57BL/6J-Slc25a13
Allele Name | targeted mutation 2.1, Kenneth R Johnson |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Slc25a13, solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 6 |
Molecular Note | exon 5 was replaced by a loxP flanked neomycin resistance cassette to generate a null allele and subsequent breeding to a Cre-deleter strain excised the neomycin resistance cassette to yield this null allele |
When using the STOCK Slc25a13tm2.1Kjn/Kjn mouse strain in a publication, please cite the originating article(s) and include JAX stock #029351 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Slc25a13<tm2.1Kjn> |
Frozen Mouse Embryo | STOCK Slc25a13<tm2.1Kjn>/Kjn | $2595.00 |
Frozen Mouse Embryo | STOCK Slc25a13<tm2.1Kjn>/Kjn | $2595.00 |
Frozen Mouse Embryo | STOCK Slc25a13<tm2.1Kjn>/Kjn | $3373.50 |
Frozen Mouse Embryo | STOCK Slc25a13<tm2.1Kjn>/Kjn | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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