H1R KO mice have a neo cassette, in reverse orientation to the gene, replacing the initiation codon of the histamine receptor H1 (Hrh1) gene, abolishing gene expression. Homozygotes are viable and fertile. H1R is a G protein-coupled receptor that mediates the contraction of smooth muscles and neurotransmission in the central nervous system. It is involved in multiple processes including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to inflammatory responses and allergic reactions. H1R KO mice have increased amounts of brown and white adipose tissue, with increased body weight after 28 weeks of age. At 48 weeks of age mice have decreased circulating insulin levels, with increased leptin, free fatty acid, and triglyceride levels. These mice also display decreased T and B cell proliferation, and decreased levels of some immunoglobulins such as IgM and IgG3 following stimulation with ovalbumin.

Histamine receptor H1 (H1R) KO mice may be useful when studying the role of histamine during allergic reaction and the regulation of neurotransmission.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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