CCR7 Tg transgenic mice have a human CD2 antigen (CD2) promoter directing expression of a chemokine (C-C motif) receptor 7 (Ccr7) cDNA. CCR7 is a G protein-coupled receptor involved in the migration of memory T cells to from peripheral tissues into draining lymph nodes. Homozygous CCR7 Tg mice are viable and fertile. 
CD4+ and CD8+ T cells from the lymph nodes of CCR7 Tg transgenic mice have slightly elevated expression of CCR7. In a model of allergic airway inflammation, CCR7+ effector T cells enter inflamed tissue and continue to migrate into the lymph system, whereas CCR7- T cells accumulate in the inflamed lung.

CCR7 Tg transgenic mice express Ccr7 cDNA in T lymphocytes under control of a human CD2 promoter. These mice may be useful in applications related to T cell exit from peripheral tissue.

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