TRE/TrfT mice have a tet-responsive element (TRE; tetO) placed upstream of the human transferrin (TRF) cDNA and a &beta;-globin polyadenylation signal. Mice hemizygous for this transgene are viable and fertile. The donating investigator has not attempted to make this strain homozygous. TRF is an iron-binding blood plasma glycoprotein that is involved in the transport of iron from sites of absorption and heme degradation to those of storage and utilization. When bred with another mouse expressing tetracycline-controlled transactivator protein (tTA) or reverse tetracycline-controlled transactivator protein (rtTA), transferrin expression in the resulting double mutant offspring can be regulated with tetracycline or its analog doxycycline (dox).

These TRE/TrfT mice express human transferrin under direction of A tet-responsive element (TRE; tetO). These mice may be useful when studying iron transport.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.