These transgenic mice express a soluble form of chicken ovalbumin under the control of the mouse Mt1 promoter. Protein can be detected circulating in the serum.
Katrina Hoyer, University of California, Merced
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
These mtOVA transgenic mice express a serum-soluble form of chicken ovalbumin (sOVA) under the regulatory control of the mouse Mt1 (metallothionein 1) promoter.
Adoptive transfer of OVA-specific T cells from DO11 mice (see Stock No. 003303) into the mtOVA mice have been used to study immune responses to self-antigen. They were instrumental in demonstrating that B7 molecules promote effective T cell priming and contain effector responses when self-antigens are presented as foreign.
Chicken ovalbumin peptide (OVA323-339) is expressed under the control of the mouse Mt1 (metallothionein 1) promoter in this transgenic strain. This line was backcrossed to BALB/cJ for more than 10 generations by the donating investigator.
Expressed Gene | OVA, ovalbumin, chicken |
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Site of Expression | T-cells. |
Allele Name | transgene insertion 1, Abul Abbas |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | sOVA Tg; sOVA-Tg |
Gene Symbol and Name | Tg(Mt1-OVA)1Akab, transgene insertion 1, Abul Abbas |
Gene Synonym(s) | |
Promoter | Mt1, metallothionein 1, mouse, laboratory |
Expressed Gene | OVA, ovalbumin, chicken |
Site of Expression | T-cells. |
Strain of Origin | FVB |
Chromosome | UN |
Molecular Note | A soluble ovalbumin was expressed under the control of the metallothionein promoter. |
Hemizygotes and homozygotes are viable and fertile.
When using the mtOVA mouse strain in a publication, please cite the originating article(s) and include JAX stock #028851 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or non carrier for Tg(Mt1-OVA)1Akab |
Frozen Mouse Embryo | C.FVB-Tg(Mt1-OVA)1Akab/J | $2595.00 |
Frozen Mouse Embryo | C.FVB-Tg(Mt1-OVA)1Akab/J | $2595.00 |
Frozen Mouse Embryo | C.FVB-Tg(Mt1-OVA)1Akab/J | $3373.50 |
Frozen Mouse Embryo | C.FVB-Tg(Mt1-OVA)1Akab/J | $3373.50 |
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