Beclin 1, encoded by the Becn1 gene, plays a central role in autophagy regulation and is involved in early embryonic development, tumorigenesis, tumor progression and neurodegeneration. These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 2 deleted in the cre-expressing tissues.
Removal of the floxed sequence creates a null allele. 

 When bred to a strain with Cre recombinase expression in Purkinje cells (see Stock No. <a href="https://www.jax.org/strain/004146"">004146</a> for example), or other neurons, this mutant mouse strain may be useful in applications related to neurodegeneration.

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These floxed mutant mice possess loxP sites flanking exon 2 of the Becn1 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of autophagy, tumorigenesis, tumor progression and neurodegeneration.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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