The targeted Fgf3 gene encodes an oncogenic fibroblast growth factor involved in inner ear development. Mutations in the Fgf3 gene have been associated with Deafness, Congenital With Inner Ear Agenesis, Microtia, And Microdontia and Deafness With Labyrinthine Aplasia Microtia And Microdontia. The targeted Fgf4 gene encodes an oncogenic fibroblast growth factor involved in limb development. Both Fgf3 and Fgf4 are important for embryonic axis extension. Mutations in the Fgf4 gene have been associated with Karposi sarcoma. Amplification and elevated levels of FGF3 and FGF4 is found in several types of cancer. 


These mice carry a knock-out allele of the Fgf3 gene and a floxed allele of the Fgf4 gene, in cis (both genes are on Chromosome 7).

Fgf3&Delta;-Fgf4flox mice, homozygous for both alleles, are viable, fertile and exhibit shortened tail length compared to double heterozygotes and wildtype littermates. Circling or head-tilt behavior is incompletely penetrant in Fgf3&Delta;-Fgf4flox homozygotes.

When crossed to a strain with Cre recombinase expression in the mesodermal lineages, or germline Cre recombinase expression, this mutant mouse strain may be useful in studies of fibroblast growth factors during development.

These Fgf3&Delta;-Fgf4flox mice carry a knock-out allele of the Fgf3 gene and a floxed allele of the Fgf4 gene in cis. When bred to a strain expressing Cre recombinase, the resulting offspring will have exons 2 and 3 of Fgf4 deleted in the cre-expressing tissues.
These mice are suitable for useful for generating conditional mutations in applications related to the functional redundancy of Fgf3 and Fgf4 during embryogenesis, development and disease.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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