These FBXL3 A220T mutant mice carry an A220T amino acid (G to A base pair) ENU-derived mutation in the Fbxl3 gene. Homozygous mice display a long circadian rhythm (Tau approximately 25.5 hours).
Dr. Joseph S. Takahashi, Univ Texas Southwestern Medical Ctr
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Chemically induced (ENU) (Not Applicable) | Fbxl3 | F-box and leucine-rich repeat protein 3 |
These mutant mice carry an A220T amino acid ENU-derived mutation in the Fbxl3 (F-box and leucine-rich repeat protein 3) gene. Homozygous mice display a long circadian rhythm (Tau approximately 25.5 hours). Mutant protein is expressed at normal levels in the liver.
A single G to A base pair change, generated through ENU mutagenesis of C57BL/6J males, created an A220T amino acid change in the Fbxl3 gene. This strain was maintained on a C57BL/6J background by the donating lab.
Allele Name | mutation 1, Joseph S Takahashi |
---|---|
Allele Type | Chemically induced (ENU) (Not Applicable) |
Allele Synonym(s) | |
Gene Symbol and Name | Fbxl3, F-box and leucine-rich repeat protein 3 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 14 |
Molecular Note | ENU mutagenesis generated a single G to A base pair change creating an A220T amino acid change in the gene. |
Heterozygous and homozygous mice are viable and fertile.
When using the FBXL3 A220T mouse strain in a publication, please cite the originating article(s) and include JAX stock #028617 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Fbxl3<m1Jt> |
Frozen Mouse Embryo | C57BL/6J-Fbxl3<M1Jt>/J | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Fbxl3<M1Jt>/J | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Fbxl3<M1Jt>/J | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Fbxl3<M1Jt>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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