C57BL/6J-Fbxl3^M1Jt/J

Stock number: 028617
Product name: FBXL3 A220T
Research areas: Neurobiology Research

Description

These FBXL3 A220T mutant mice carry an A220T amino acid (G to A base pair) ENU-derived mutation in the Fbxl3 gene. Homozygous mice display a long circadian rhythm (Tau approximately 25.5 hours).

Detailed description

These mutant mice carry an A220T amino acid ENU-derived mutation in the Fbxl3 (F-box and leucine-rich repeat protein 3) gene. Homozygous mice display a long circadian rhythm (Tau approximately 25.5 hours). Mutant protein is expressed at normal levels in the liver.

Development

A single G to A base pair change, generated through ENU mutagenesis of C57BL/6J males, created an A220T amino acid change in the Fbxl3 gene. This strain was maintained on a C57BL/6J background by the donating lab.

Allele

Symbol: Fbxl3^M1Jt
Name: mutation 1, Joseph S Takahashi
MGI accession ID: MGI:5752834
Generation method: Chemically induced (ENU)
Attributes: Not Applicable
Marker symbol: Fbxl3
Marker name: F-box and leucine-rich repeat protein 3
Marker synonyms: FBL3; FBL3A; Fbxl3a; IDDSFAS; Ovtm; Play68
Chromosome: 14
Strain of origin: C57BL/6J
Molecular note: ENU mutagenesis generated a single G to A base pair change creating an A220T amino acid change in the gene.