The Cyp17a1 gene encodes a cytochrome P450 enzyme that is involved in fetal and pubescent sexual development. These transgenic mice express iCre recombinase under the control of the mouse cytochrome P450, family 17, subfamily a, polypeptide 1, gene promoter. 
When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the Cre expressing tissues. Cre recombinase activity is detected in ovarian theca and interstitial cells, testis Leydig cells, pituitary gland intermediate lobe and liver. Weaker Cre recombinase activity is observed in the oviduct and uterus, and in gonadotropin-primed ovarian granulosa cells, as well as kidney, adrenal gland, spleen, lung and brain. At embryonic day 16.5, Cre recombinase is expressed in the testis. Mice that are homozygous for the transgene are viable and fertile.

These Cyp17iCre transgenic mice have the mouse Cyp17a1 promoter driving codon optimized iCre recombinase expression in the ovarian theca/interstitial cells and Leydig cells in the testis.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.