Slack (Slo2.2) floxed mice possess loxP sites flanking exon 11 of the potassium channel, subfamily T, member 1 (Kcnt1) gene. KCNT1 encodes a subunit of a sodium activated potassium channel expressed in neurons throughout the brain. SLACK is involved in the regulation of neuronal excitability and the rate of adaptation in response to repeated stimulation. Mutations in this gene have been associated with Early Infantile Epileptic Encephalopathy and Fragile X syndrome. Slack floxed mice that are homozygous for this allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 11 of the Kcnt1 gene deleted in cre-expressing tissues.

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Slack (Slo2.2) floxed mice possess loxP sites flanking exon 11 of the Kcnt1 gene, making this strain useful for studying the regulation of neuronal excitability and intellectual disabilities caused by mutations in Slack channels.

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