Hyperacetylation of MAPT (tau) lysines K274 and K281, which are within the microtubule-binding domain region, has been found in the brains of Alzheimer’s disease patients with dementia.
These transgenic mice express the human tauKQ MAPT
isoform under the direction of the mouse prion protein promoter. The human tauKQ (MAPT) transgene contains lysine-to-glutamine mutations that recapitulate abnormal MAPT K274 and K281 acetylation (ac-K274 and ac-K281). Transgene expression is detected in hippocampal lysates by western blot analysis, and in hippocampus, cortex, and cerebellum by in situ hybridization. Transgenic mice exhibit caspase-cleaved MAPT protein in the hippocampus and increased misfolded MAPT protein in mossy fibers.
Hippocampal long-term potentiation, spatial memory and memory retention are impaired in transgenic mice.
Mice that are hemizygous for the transgene are viable and fertile. Homozygous viability/fertility has not been tested (November, 2016).

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These tauKQhigh mice express human MAPT (tau) with mutations to mimic abnormal acetylation in the brain and have applications related to the study of Alzheimer’s disease and other tauopathies.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.