Csf1rdex5 KO mice lack exon 5 of the colony stimulating factor 1 receptor (Csf1r) gene, abolishing gene expression. Csf1r encodes Cd115 which acts as the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. Expressed in macrophages, expression is also seen in oocytes, osteoclasts, trophoblasts, CNS microglia, and some myoblasts. Heterozygous Csf1rdex5 mice are viable and fertile, while, homozygous mice die by 3 weeks of age. They also have smaller body sizes compared to wildtype mice. Mice have osteoporosis and lack teeth.
