Pax6, a member of the Pax family, encodes a homeobox and paired domain-containing protein that functions as a transcription factor and is expressed in pancreatic endocrine cells as well as the eye, nose and central nervous system. Pax6-LacZ KO mice contain a &#946-galactosidase gene that replaces the start codon and paired domain of the Pax6 gene. &#946-galactosidase activity mimics endogenous Pax6 expression and is detected in live embryos. Mice homozygous for mutation die shortly after birth and exhibit a phenotype similar to small eye mutants (Pax6Sey); pups lack eyes and the olfactory bulb. In addition, the islets of Langerhans are disorganized and the glucagon-producing &#945 cell lineage is eliminated. This strain may be useful for lineage tracing of Pax6+ cells and for studying endocrine cell differentiation in early pancreatic development.

Pax6-LacZ KO mice contain a &#946-galactosidase gene that replaces the start codon and paired domain of the Pax6 (paired box 6) gene. Mice homozygous for the mutation die shortly after birth. This strain may be useful for lineage tracing of Pax6+ cells and for studying endocrine cell differentiation in early pancreatic development.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.