PSA tg mice express human prostate specific antigen (KLKB1 kallikrein B, plasma 1, PSA) under control of the probasin (Pbsn) promoter. PSA is a serine protease produced at high levels by prostate epithelial cells and secreted into seminal plasma. PSA is a tumor marker for diagnosis and prognosis of prostatic carcinoma. Mice homozygous for the PSA tg allele are viable and fertile. Expression of PSA in the prostate was confirmed at the protein level by immunohistochemical staining with PSA-specific antibodies. Mice expressed PSA in ventral, dorsal and lateral prostate lobes, whereas the anterior prostate did not express detectable PSA. These mice have been developed to test the utility of mouse CMV (mCMV)-based vaccines expressing human prostate specific antigen (PSA) for prostate cancer immunotherapy.

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PSA tg mice express human prostate specific antigen, KLKB1, under control of the probasin promoter, on a congenic B6 background. These mice are useful for studying CMV-based vectors as an effective anti-tumor immune response in a mouse model of prostate cancer.

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B6.Cg-Tg(Pbsn-KLKB1)1Gja/EkvaJ Frozen Embryo