Blomia tropicalis is the predominant mite species in tropical and subtropical regions, the 4th most common mite in the United States, and an important source of aeroallergens. Blo t 5, the major Blomia tropicalis allergen, provokes a very high rate of sensitization. 
These BT-II TCR transgenic mice express the mouse &alpha;-chain and &beta;-chain T cell receptor which recognizes peptide 55–70 from the Blo t 5 antigen from Blomia tropicalis under the control of the natural TCR&alpha; and TCR&beta; promoter/enhancer elements. More than 98% CD4 T cells coexpress specific V&alpha; 11.1/11.2 and V&beta;3, as assessed by flow cytometry of peripheral blood from transgenic mice.When Blo t 5-specific T cells from these transgenic mice are transplanted to naïve mice, intranasal antigen challenge induces airway inflammation and hyperresponsiveness in the lung. 
Mice homozygous for the transgenic insert are viable and fertile.

T cells from these TCR transgenic mice recognize the Blo t 5 antigen from Blomia tropicalis. These BT-II mice are useful in studies of allergic lung inflammation associated with acute asthma.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.