These transgenic mice express the human (<i>PARK2</i>) under the direction of the mouse prion protein promoter. 
Transgenic human parkin is expressed in almost all ventral midbrain dopaminergic neurons at a 7- to 8-fold increase and in striatal dopaminergic neurons at a 3- to 4-fold increase, compared to endogenous mouse parkin protein expression levels.  When crossed to mice deficient in RET (ret proto-oncogene) the loss of dopaminergic neurons of the substantia nigra pars compacta is reduced, and total striatal dopamine levels are almost unaltered.  Mice that are hemizygous for the transgene are viable and fertile. The Donating Investigator has not attempted to make the strain homozygous.


These wt h-parkin transgenic mice express human parkin (<i>PARK2</i>) in almost all ventral midbrain dopaminergic neurons (at a 7- to 8-fold increase compared to endogenous mouse parkin protein) and may be suitable for use in studies related to neurodegeneration and Parkinson Disease.

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