Stock No. 027414 was formerly associated with CHDI Foundation colony Stock No. 370612 [CHDI-81003011].
Huntington's disease (HD) is an autosomally dominant, fatal neurodegenerative disorder characterized by uncontrolled movements, psychiatric disturbances and cognitive impairment. HD is caused by an unstable trinucleotide (polyglutamine) repeat expansion in the huntingtin gene (HTT; HD or Hdh). 
 
The Hdh (CAGCAA)9 knock-in (Hdh (CAGCAA)9 KI) allele replaces mouse Htt exon 1 with the human HTT exon 1 sequence with 45 glutamine repeats ([CAG CAA CAG CAA CAA]9]. Heterozygous mice are viable and fertile. These mice have not been further characterized to date (April 2014), but may be useful in applications exploring the effect of interrupted CAG tracts versus non-interrupted CAG tracts on somatic instability and RNA structure mechanisms in HD pathophysiology.
This Huntington's disease mouse model is available by way of a collaborative effort between CHDI Foundation, Dr. David S. Grass (Xenogen Biosciences [now Taconic Biosciences]), and The Jackson Laboratory.

The Hdh (CAGCAA)9 knock-in allele has the human HTT exon 1 sequence with 45 glutamine repeats ([CAG CAA CAG CAA CAA]9) replacing the mouse Htt exon 1. These B6N.Hdh (CAGCAA)9 KI mice may be useful for studying Huntington's disease, specifically the effect of interrupted CAG tracts versus pure CAG tracts on somatic instability and RNA structure mechanisms in HD pathophysiology.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.