BALB/cJ-Meox1^squig/GrsrJ

Stock number: 026620
Product name: squiggle tail

Description

Meox1^squig (squiggletail) homozygotes have a shortened and very curly tail. Intercrosses of heterozygotes yield approximately 25% mutants, consistent with complete penetrance. Both female and male homozygotes breed and live a normal lifespan.

Detailed description

Squiggle tail (squig) homozygotes have a shortened and very curly tail. Intercrosses of heterozygotes yield approximately 25% mutants, consistent with complete penetrance. Both female and male homozygotes breed and live a normal lifespan. In 2022, the mutation was identified as a 3195 bp deletion encompassing exon 1 of the Meox1 (mesenchyme homeobox 1) gene on chromosome 11.

Development

The recessive squiggle tail mutation arose spontaneously in the BALB/cJ inbred strain at The Jackson Laboratory, when that inbred was at generation F239, and has been maintained coisogenic on this background. Sperm was cryopreserved from homozygous males at generation +F2. In 2022, the mutation was identified as a 3195 bp deletion encompassing exon 1 of the Meox1 (mesenchyme homeobox 1) gene on chromosome 11.