These mAKAP6fl mutant mice possess loxP sites flanking exon 9 of the A kinase (PRKA) anchor protein 6 (Akap6) gene. Akap6 is a scaffold protein located in the nuclear envelope of striated myocytes; it functions as nodal organizer of hypertrophic signaling. Mice that are homozygous for this allele are viable, fertile, and normal in size. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 9 deleted in the cre-expressing tissues. This strain may be useful for studying cardiac hypertrophy and heart failure.

When bred to mice carrying Tg(Myh6-cre/Esr1*)1Jmk, tamoxifen-induced Cre-mediated recombination and stress by transverse aortic constriction results in a cardiac protective effect when compared to controls subjected to the same regime.

These mAKAP6fl mutant mice possess loxP sites flanking exon 9 of the A kinase (PRKA) anchor protein 6 (Akap6) gene, a scaffold protein located in the nuclear envelope of striated myocytes. This strain may be useful for studying cardiac hypertrophy and heart failure.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.