These mice carry a targeted mutation in which a floxed STOP cassette and mutant human LRRK2 (R1441C) sequence was inserted into the endogenous Gt(ROSA)26Sor locus. The R1441C mutation occurs in the 'Ras of complex proteins' (ROC) domain of the leucine-rich repeat kinase 2 protein, reducing GTPase activity. Homozygotes are viable and fertile.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Of note, the ROSA26-LRRK2 (R1441C) strain is also available on the original STOCK genetic background(Stock No. 022793).
