Islr2 (immunoglobulin superfamily containing leucine-rich repeat 2; also called Linx) is expressed in the peripheral nervous system, prethalamus, lateral ganglionic eminence-derived corridor, corticofugal axons and elsewhere. It binds to thalamocortical projections and promotes their outgrowth guiding them in the ventral forebrain and mediating reciprocal interactions between ascending thalamocortical and descending corticofugal axons in the internal capsule (IC) region. 

A portion of exon 3 of the mouse Islr2 gene is flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele. Mice deficient in this transmembrane protein exhibit a complete absence of the internal capsule (IC).

A portion of exon 3 of the mouse Islr2 (Linx) gene is flanked by loxP sites in this targeted mutant strain. Cre excision of the floxed region results in a knockout of the gene.

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