Med23 (mediator complex subunit 23) is a subunit of the Mediator coactivator complex, and is important in the expression of a subset of MAPK/ERK pathway-responsive genes. 

Exons 5-7 of the mouse Med23 gene are flanked by loxP sites in this conditional targeted mutant strain. Cre excision of the floxed region results in a knockout of the gene. 

Thymocyte-specific knockouts of the gene created through crosses with Lck-cre produce T cells that fail to efficiently populate peripheral lymphoid organs.

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Exons 5-7 of the mouse Med23 gene are flanked by loxP sites in this targeted mutant strain. Cre excision of the floxed region results in a knockout allele, useful in studies of transcriptional regulation in MAPK/ERK pathways.

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Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.