These mice carry a re-arranged T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for peptide P14 from the LCMV (lymphocytic choriomeningitis virus) in the context of H2-Db. The LCMV P14 T Cell Receptor transgenic is combined with a Tcra KO that does not develop endogenous mature TCR alpha beta cells. 
Almost all the peripheral T cells are CD8+ and express the transgenic TCR. The mice are useful for in vitro studies of CD8+ T cell activation and differentiation to cytotoxic lymphocytes and as a source of donor cells for adoptive transfer into C57BL/6 mice for in vivo studies of inflammation, tolerance and anti-viral responses.

This strain is currently unavailable due to replenishing of cryopreserved stocks and will become available from cryopreservation again once the cryopreseved bankstock has been replenished. &nbsp;&nbsp;These mice carry a re-arranged T-cell receptor specific for LCMV peptide P14 and a Tcra KO that does not develop endogenous mature TCR alpha beta cells. This strain may be useful for studying CD8+ T cell activation and differentiation and as a source of donor cells for adoptive transfer for in vivo studies of inflammation, tolerance and anti-viral responses.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.