The witch nails mutation provides novel insight into the function of this gene.
Read More +Genetic Background | Generation |
---|---|
000664 C57BL/6J |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | Krt90 | keratin 90 |
Witch nail homozygotes develop very long toenails on all digits by 2 months of age. The nail bed is normal but the nail is thickened and elongated. X-rays of 5 homozygotes indicated the presence of additional caudal vertebrae in some but not all mutants.
The witch nails mutation arose spontaneously in the MRL/MpJ-Faslpr/J strain at The Jackson Laboratory in 2001. This mutation was backcrossed onto the C57BL/6J background and sperm was cryopreserved from homozygous males at generation N5.
Allele Name | witch nails |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Krt90, keratin 90 |
Gene Synonym(s) | |
Strain of Origin | MRL/MpJ-Faslpr/J |
Chromosome | 15 |
Molecular Note | This spontaneous 7 base pair duplication insertion of AGCCTGT in exon 9 causes a serine to arginine substitution at amino acid 476 followed by a frameshift leading to 36 novel amino acids and then a premature stop codon. |
When using the witch nails mouse strain in a publication, please cite the originating article(s) and include JAX stock #024690 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for whnl |
Frozen Mouse Embryo | B6.MRL-Krt90<whnl>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.MRL-Krt90<whnl>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.MRL-Krt90<whnl>/GrsrJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.MRL-Krt90<whnl>/GrsrJ Frozen Embryos | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.