This spontaneous mutation causes homozygotes to drag one of both hind feet or legs when walking
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Not Applicable) | flim | flimsy hind leg |
Mice homozygous for the flimsy hind leg mutation drag one or both hind feet or legs when walking. There is variable expressivity such that some homozygotes clearly display the phenotype at wean age while other have a more mild phenotype with a slightly later presentation. In some homozygotes one hind leg is more severely impacted than the other or is faster to present the phenotype. This spontaneous mutation has been mapped to Chromosome 2 with no recombinants of 12 mutants assessed for rs3682381 and no recombinants of 10 mutants assessed for rs4223212.
The flimsy hind leg mutation (flim) arose spontaneously in the B6.CB17-Prkdcscid/SzJ strain at The Jackson Laboratory and the Prkdcscid mutation was bred out of this mutant subline by two cycles of backcross-intercross breeding to C57BL/6J. Sperm was cryopreserved from homozygous males.
When using the B6.Cg-flim/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #024582 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for flim |
Frozen Mouse Embryo | B6.Cg-flim/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-flim/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-flim/GrsrJ | $3373.50 |
Frozen Mouse Embryo | B6.Cg-flim/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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