Mice homozygous for the hotfoot 20 Jackson mutation have an abnormal, wobbly gait and a tremor, evident by 6 to 8 weeks of age.
The hotfoot 20 Jackson mutation arose spontaneously in the B6.Cg-Lepob/J strain at The Jackson Laboratory in late 2012 and the obese mutation was bred out with one backcross to C57BL/6J and sperm was cryopreserved from homozygous males in 2014.
|Allele Name||hotfoot 20 Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Grid2, glutamate receptor, ionotropic, delta 2|
|Strain of Origin||B6.Cg-Lepob/J|
|Molecular Note||Failed complementation test proved this spontaneous mutation allelic with hotfoot 18 Jackson and hotfoot 19 Jackson.|