Gata6 Tg mice express GATA binding protein 6 (Gata6) cDNA under control of a tetracycline operator (tetO). Hemizygotes are viable and fertile. GATA6 is a zinc-finger-containing transcription factor involved in the regulation of early axial patterning, cellular differentiation, and organogenesis. Expressed is first seen at the eight-cell stage, and is predominately seen in forelimb buds and hindlimb buds in an anterior to posterior gradient in developing embryos. When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of GATA6 protein may be regulated with tetracycline or its analog doxycycline (dox) in the double mutant offspring.

Gata6 Tg mice express Gata6 cDNA under control of a tetracycline operator. When mated to a mutant strain expressing a tetracycline-controlled transactivator protein, expression of GATA6 may be regulated with doxycycline. These mice may be useful when studying embryonic axial patterning.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.