Golga3 or golgi autoantigen a3 encodes a member of the golgin family of proteins associated with the Golgi complex and has regulatory roles in protein trafficking, apoptosis, Golgi complex positioning and spermatogenesis. The repro27 mutation is a premature stop codon that results in the absence of protein expression. Male mice homozygous for the mutation are sterile. Spermatogenesis is disrupted in late meiosis and significant germ cell loss occurs between 15-18 days post-partum due to apoptosis. Surviving spermatids exhibit defective acrosome formation, abnormal head and tail development and vacuolization in seminiferous epithelium. Spermatozoa are found in low concentrations with diminished motility. The donating investigator reports that the phenotype is more severe on the C57BL/6J background.

This strain may be useful for studying the role of golgin in male infertility.

Male mice homozygous for the null Golga3 or golgi autoantigen a3 allele (repro27) are sterile and exhibit significant germ cell loss due to apoptosis. Surviving spermatids exhibit multiple defects. The donating investigator reports that the phenotype is more severe on the C57BL/6J background.

This strain may be useful for studying the role of golgin in male infertility.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.