STOCK Stmb/GrsrJ

Stock number: 024238
Product name: stumbles
Research areas: Neurobiology Research

Description

At approximately five to eight months of age stumbles (Stmb) heterozygotes develop an abnormal gait in which they stagger and fall over. The front legs appear hesitant in the first movement of walking. The ataxic phenotype persists when outcrossed to C57BL/6J. Rather than the 50% expected mutant offspring from heterozygous to wildtype intercrosses, only approximately one third of offspring developed this ataxia by eight months of age.

Detailed description

At approximately five to eight months of age stumbles (Stmb) heterozygotes develop an abnormal gait in which they stagger and fall over. The front legs appear hesitant in the first movement of walking. The ataxic phenotype persists when outcrossed to C57BL/6J. Rather than the 50% expected mutant offspring from heterozygous to wildtype intercrosses, only approximately one third of offspring developed this ataxia by eight months of age.

Development

Stumbles arose spontaneously in the NONcNZO10/LtJ strain at The Jackson Laboratory and sperm was cryopreserved from heterozygous males when the strain was at generation +F8. Standard cryorecovery is scheduled to use C57BL/6J oocytes.

Allele

Symbol: Stmb
Name: stumbler
MGI accession ID: MGI:5780143
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Stmb
Marker name: stumbles
Chromosome: UN
Strain of origin: NONcNZO10/LtJ
Molecular note: This heritable phenotype arose spontaneously at The Jackson Laboratory.