Hemizygous Ngn3-Cre mice are viable and fertile. Expression of the transgene is directed by a neurogenin 3 (Neurog3) promoter in all endocrine cell types in the pancreatic islet. When bred with a mouse containing a loxP site-flanked sequence of interest, cre-mediated recombination results in deletion of the flanked gene in islets.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Ngn3-Cre mice express Cre Recombinase in all endocrine cell types in the pancreatic islet. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked gene in neurogenin 3 expressing tissues.

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