LIN28A (lin-28 homolog A (C. elegans)) is an RNA-binding protein that blocks biogenesis of Mirlet7 (let-7) microRNAs. Let-7 targets are known regulators of mammalian body size and metabolism.

These mice carry a germline knockout of the Lin28a gene. Homozygous mice show dwarfism as early as E13.5 and by E18.5 demonstrate a 20% reduction in weight relative to heterozygous controls. Although born at expected Mendelian ratios, roughly 93% of Lin28a knockout mice die within 1 day of birth (2 out of 5 mice harboring a cardiac ventricular septal defect). Those animals that survive are 30-50% smaller in weight and 20-30% shorter in length than controls. Dual-energy x-ray absorptiometry imaging confirms a decreased fat mass and also reveals decreased bone mineral density in the knockout animals, suggesting that these animals suffer from metabolic dysregulation.

These mice carry a germline knockout of the Lin28a (lin-28 homolog A (C. elegans)) gene. Homozygous mice show dwarfism and most die within 1 day of birth (many showing cardiac ventricular septal defects). Survivors exhibit decreased bone mineral density.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.