Expression of Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) begins in spinal cord radial glia at the time of their commitment to gliogenesis. 
This transgenic strain expresses Cre from the mouse Aldh1l1 promoter. When crossed with a Gt(ROSA)26Sor-YFP floxed reporter strain, glial cells of the spinal cord exhibit fluorescence. Seventy-five percent of labeled cells also express GFAP (glial fibrillary acidic protein; a marker for astrocytes) and 15% co-express OLIG2 (oligodendrocyte transcription factor 2; a marker for oligodendrocytes). Only 10% express RBFOX3 (RNA binding protein, fox-1 homolog (C. elegans) 3; a marker for neurons, also called NeuN).

This transgenic strain expresses cre recombinase from the mouse Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) promoter. This strain enables tissue-specific excision of floxed genomic segments in astrocytes as well as some oligodendrocytes and neurons.

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