Mutations in the human CSNK1D (casein kinase 1, delta) gene have been associated with symptoms of Familial Advanced Sleep Phase Syndrome (FASPS). Evidence suggests that this kinase interacts with PER2 (period circadian clock 2) binding domains to regulate circadian period.
Hemizygous transgenic mice express 2-3 copies of the full-length, wildtype human gene. Under 12 hour light-12 hour dark (LD) and constant darkness (DD)conditions, these mice and T44A transgenic mutant mice (see Stock No. 022148) show similar and robust circadian rhythms of wheel-running activity. Transgenic mice carrying this wildtype form of the human gene exhibit a circadian period of approximately 23.78 hours, but when placed in combination with a Per2 S662G mutation (e.g. Stock No. 013456 or Stock No. 013700), which shortens circadian time to 22 hrs, the wildtype CSNK1D transgene further shortens the circadian period to 20.8 hours.
No phenotypic differences have been observed between this strain and founder line 432 (see Stock No. 022149).
