Rab11Fip5 (RAB11 family interacting protein 5 (class I)) encodes a protein that interacts specifically with RAB11, which is key for endocytosis. In particular, Rab11Fip5 is required for transport in apical membranes. Preliminary investigations suggest a potential role for this gene in synaptic terminal exocytosis-endocytosis events and plasticity with potential relevance to autism.

In this conditional mutant strain, exon 2 of the Rab11fip5 gene is flanked by loxP sites. Mice homozygous for this allele are viable and fertile and produce normal levels of RAB11FIP5 protein. When crossed with a Cre-expressing strain or infected with Cre-expressing virus, the floxed allele is excised and expression of the mRNA is abolished.

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In this conditional mutant strain, exon 2 of the Rab11fip5 (RAB11 family interacting protein 5 (class I)) gene is flanked by loxP sites.

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C57BL/6-Rab11fip5<tm1Sud>/J Frozen Embryo