MCK-PPARgamma transgenic mice express mouse Pparg (peroxisome proliferator activated receptor gamma ) cDNA under the direction of the mouse muscle creatine kinase (Ckm)promoter. PPARG is a nuclear receptor that regulates the transcription of multiple genes. PPARG is associated with obesity, diabetes, atherosclerosis and cancer. Hemizygous mice are viable and fertile. These mice exhibit improved glucose tolerance, especially in females, and a marked increase in insulin signalling in skeletal muscle. This strain may be useful for studying type 2 diabetes and obesity.

MCK-PPARgamma transgenic mice express mouse peroxisome proliferator activated receptor gamma cDNA under the direction of the mouse muscle creatine kinase promoter.  Mice exhibit improved glucose tolerance and an increase in insulin signalling in skeletal muscle. This strain may be useful for studying type 2 diabetes and obesity.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.