BXSB.B6-Yaa⁺/MobJDcrJ

Stock number: 021330
Product name: BXSB-Yaa⁺
Strain synonyms: BXSB-wt, BXSB.Yaa^C57BL/6, BXSB.B6-Yaa⁺, BXSB.Yaa^B6, BXSB.Yaa^C57BL/6
Research areas: Immunology, Inflammation and Autoimmunity Research, Mouse/Human Gene Homologs

Description

BXSB.B6-Yaa⁺ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). As such, BXSB.B6-Yaa⁺ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.

Detailed description

These BXSB.B6-Yaa⁺ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). Male as well as female BXSB.B6-Yaa⁺ mice do not develop the severe systemic lupus erythematosus (SLE)-like autoimmune disease that spontaneously develops in BXSB/MpJ male mice. BXSB.B6-Yaa⁺ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.

Development

The Y-linked autoimmune accelerator locus (Yaa) on the Y chromosome of BXSB inbred male mice is the result of a duplication of an ~4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. The duplicated segment contains 19 genes, including toll-like receptor 7 (Tlr7) and phosphoribosyl pyrophosphate synthetase 2 (Prps2). The BXSB-derived Yaa locus is attributed to the systemic lupus erythematosus (SLE)-like autoimmune disease characteristics observed in BXSB/MpJ inbred male mice.

These BXSB.B6-Yaa⁺ mice (Stock No. 021330) are a BXSB-consomic control strain that was bred to harbor the C57BL/6-derived wildtype allele of Yaa in place of the BXSB/MpJ-derived Yaa allele. The strain history is shown below.


First, BXSB/MpJ inbred females (Stock No. 000740) were bred to C57BL/6J inbred males (Stock No. 000664). Each successive generation, male offspring with the C57BL/6J-derived Y chromosome were bred with BXSB/MpJ inbred females. The congenic strain after ten generations of backcrossing is BXSB.B6-Yaa⁺/J (N10; Stock No. 000742).
Around 1998, Drs. Larry E. Mobraaten and Derry C. Roopenian (The Jackson Laboratory) obtained some BXSB.B6-Yaa⁺/J males from The Jackson Laboratory Repository and continued the backcrossing for additional generations. The congenic strain after at least 22 generations of backcrossing is BXSB.B6-Yaa⁺/MobJDcr (N22; Stock No. 001925).
In 2013, Dr. Roopenian sent some mice at generation N40 to The Jackson Laboratory Repository to establish Stock No. 021330.

Allele

Symbol: +
Name: wild type
MGI accession ID: MGI:2432482
Generation method: Not Applicable
Marker symbol: Yaa
Marker name: accelerated autoimmunity and lymphoproliferation transposition
Chromosome: Y
Strain of origin: Not Applicable