BXSB.B6-Yaa+ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). As such, BXSB.B6-Yaa+ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.
Dr. Derry Roopenian, The Jackson Laboratory
BXSB.B6-Yaa+ consomic males carry the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice. BXSB.B6-Yaa+ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: Stock No. 021330 are backcrossed at least 40 generations, Stock No. 001925 are backcrossed at least 22 generations, and Stock No. 000742 are backcrossed at least 10 generations.
These BXSB.B6-Yaa+ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). Male as well as female BXSB.B6-Yaa+ mice do not develop the severe systemic lupus erythematosus (SLE)-like autoimmune disease that spontaneously develops in BXSB/MpJ male mice. BXSB.B6-Yaa+ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.
The Y-linked autoimmune accelerator locus (Yaa) on the Y chromosome of BXSB inbred male mice is the result of a duplication of an ~4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. The duplicated segment contains 19 genes, including toll-like receptor 7 (Tlr7) and phosphoribosyl pyrophosphate synthetase 2 (Prps2). The BXSB-derived Yaa locus is attributed to the systemic lupus erythematosus (SLE)-like autoimmune disease characteristics observed in BXSB/MpJ inbred male mice.
These BXSB.B6-Yaa+ mice (Stock No. 021330) are a BXSB-consomic control strain that was bred to harbor the C57BL/6-derived wildtype allele of Yaa in place of the BXSB/MpJ-derived Yaa allele. The strain history is shown below.
First, BXSB/MpJ inbred females (Stock No. 000740) were bred to C57BL/6J inbred males (Stock No. 000664). Each successive generation, male offspring with the C57BL/6J-derived Y chromosome were bred with BXSB/MpJ inbred females. The congenic strain after ten generations of backcrossing is BXSB.B6-Yaa+/J (N10; Stock No. 000742).
Around 1998, Drs. Larry E. Mobraaten and Derry C. Roopenian (The Jackson Laboratory) obtained some BXSB.B6-Yaa+/J males from The Jackson Laboratory Repository and continued the backcrossing for additional generations. The congenic strain after at least 22 generations of backcrossing is BXSB.B6-Yaa+/MobJDcr (N22; Stock No. 001925).
In 2013, Dr. Roopenian sent some mice at generation N40 to The Jackson Laboratory Repository to establish Stock No. 021330.
To maintain the live BXSB.B6-Yaa+ colony (Stock No. 021330), BXSB/MpJ inbred females (Stock No. 000740) are bred with males hemizygous for the Y-linked C57BL/6-derived Yaa+ every generation.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided,
their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of
each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders
are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in
order to provide the minimum number of animals, animals will ship within 25 weeks.
The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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