These TALH-HHO1 transgenic mice express human heme oxygenase (decycling) 1 (HMOX1) or HO-1 in the thick ascending loop of Henle as well as the renal medulla and cortex. In response to angiotensin II infusion, mice exhibit lower blood pressure than non-transgenic mice. This strain may be useful for studying the role of heme oxygenase in hypertension.
David Stec, University of Mississippi Medical Center
| Genetic Background | Generation |
|---|---|
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| Allele Type |
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| Transgenic (Inserted expressed sequence, Humanized sequence) |
