These transgenic mice express human heme oxygenase (decycling) 1 (HMOX1) or HO-1 cDNA under the control  of the human uromodulin (UMOD) or TALH promoter. RT-PCR and microscopy confirm that HO-1 expression is elevated in the thick ascending loop of Henle (TALH) as well as the renal medulla and cortex, however heme oxygenase (HO) activity is increased only in the medulla.  HO is a rate limiting enzyme involved in the catabolism of heme to biliverdin. 
Hemizygous mice are viable, fertile, and normal in size.   Transgenic mice exhibit lower blood pressure than non-transgenic mice in response to angiotensin II induced hypertension.
This strain may be useful for studying the role of heme oxygenase in hypertension.


These TALH-HHO1 transgenic mice express human heme oxygenase (decycling) 1 (HMOX1) or HO-1 in the thick ascending loop of Henle as well as the renal medulla and cortex. In response to angiotensin II infusion, mice exhibit lower blood pressure than non-transgenic mice.
This strain may be useful for studying the role of heme oxygenase in hypertension.


This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. <b>For additional information and to purchase, please visit the MMRRC site.</b>