(C3H/HeJ x AKR/J-Atp8a2^agil-2J/J)F1

Stock number: 021203
Product name: agitans-like 2 Jackson
Research areas: Developmental Biology Research, Neurobiology Research

Description

Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.

Detailed description

Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.

Development

The agitans-like 2 Jackson mutation arose spontaneously in the AKR/J inbred strain at The Jackson Laboratory in 2006, when that inbred was at generation F250. This mutation was maintained the AKR/J inbred background by sibling breeding and sperm was cryopreserved from heterozygous males in 2013, and IVF recovery has been successful using C3H/HeJ ooctyes.

Allele

Symbol: Atp8a2^agil-2J
Name: agitans-like 2 Jackson
MGI accession ID: MGI:3805719
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Atp8a2
Marker name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Chromosome: 14
Strain of origin: AKR/J
Molecular note: This mutation failed to complement in an allele test with the original agil mutation, which failed to complement in an allele test with the agil-3J allele, which was found to be a mutation in this gene.