Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Not Specified) | Atp8a2 | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.
The agitans-like 2 Jackson mutation arose spontaneously in the AKR/J inbred strain at The Jackson Laboratory in 2006, when that inbred was at generation F250. This mutation was maintained the AKR/J inbred background by sibling breeding and sperm was cryopreserved from heterozygous males in 2013, and IVF recovery has been successful using C3H/HeJ ooctyes.
Allele Name | agitans-like 2 Jackson |
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Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Atp8a2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Gene Synonym(s) | |
Strain of Origin | AKR/J |
Chromosome | 14 |
Molecular Note | This mutation failed to complement in an allele test with the original agil mutation, which failed to complement in an allele test with the agil-3J allele, which was found to be a mutation in this gene. |
When using the agitans-like 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #021203 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
Frozen Mouse Embryo | (C3H/HeJ x AKR/J-Atp8a2<agil-2J>/J)F1 | $2595.00 |
Frozen Mouse Embryo | (C3H/HeJ x AKR/J-Atp8a2<agil-2J>/J)F1 | $2595.00 |
Frozen Mouse Embryo | (C3H/HeJ x AKR/J-Atp8a2<agil-2J>/J)F1 | $3373.50 |
Frozen Mouse Embryo | (C3H/HeJ x AKR/J-Atp8a2<agil-2J>/J)F1 | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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