Mice heterozygous for the KitW-85J mutation have normal hearing but white spots on an otherwise black coat. Homozygotes have black eyes but an all white coat.
The KitW-85J mutation arose spontaneously on the C57BL/6J inbred strain background and was kept coisogenic on that background. In 2013 sperm was cryopreserved from heterozygous males.
|Allele Name||dominant spotting 85 Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Kit, KIT proto-oncogene receptor tyrosine kinase|
|Strain of Origin||C57BL/6J|
|Molecular Note||A spontaneous C-to-T transition in Chromosome 5 position 75,652,822 (GRCm38) results in an arginine to tryptophan mutation at position 890 (p.R890W).|