Caracul 19 Jackson heterozgyotes have the wavy coat and wavy vibrissae typical of keratin 71 mutations. Histology of three heterozgyotes found mild dermatitis on the snout of two and one of those also had hyperplastic mammary ducts.
This mutation arose spontaneously in the BALB/cJ inbred strain at The Jackson Laboratory and has been maintained coisogenic on this background ever since.
|Allele Name||caracul 19 Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Krt71, keratin 71|
|Strain of Origin||BALB/cJ|
|Molecular Note||This spontaneous C-to-T transition at chromosome 15 position 101,736,558 bp (GRCm38) results in a glutamic acid to lysine amino acid substitution at position 440 (p.E440K).|
When using the BALB/cJ-Krt71Ca-19J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #021060 in your Materials and Methods section.