BALB/cJ-Krt71^Ca-19J/GrsrJ

Stock number: 021060
Research areas: Dermatology Research, Developmental Biology Research

Description

This mutation provides a model for hypotrichosis 13

Detailed description

Caracul 19 Jackson heterozgyotes have the wavy coat and wavy vibrissae typical of keratin 71 mutations. Histology of three heterozgyotes found mild dermatitis on the snout of two and one of those also had hyperplastic mammary ducts.

Development

This mutation arose spontaneously in the BALB/cJ inbred strain at The Jackson Laboratory and has been maintained coisogenic on this background ever since.

Allele

Symbol: Krt71^Ca-19J
Name: caracul 19 Jackson
MGI accession ID: MGI:5586972
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Krt71
Marker name: keratin 71
Chromosome: 15
Strain of origin: BALB/cJ
Molecular note: This spontaneous C-to-T transition at chromosome 15 position 101,736,558 bp (GRCm38) results in a glutamic acid to lysine amino acid substitution at position 440 (p.E440K).