These transgenic mice express human KLF4, Kruppel-like factor 4, under the direction of the tetracycline operator promoter (tetO). Mice hemizygous for the transgenic insert are viable and fertile. It is not known if homozygotes are viable. When mated to mice carrying K14-rtTA (also known as Tg(KRT14-rtTA)208Jek)), KLF4 expression is directed to basal keratinocytes and regulated with tetracycline or its analog doxycycline (DOX). Following DOX induction, bitransgenic mice exhibit hyperkeratosis, atrophy of sebaceous glands, cystic degeneration of hair follicles and hyperplasia. This strain may be useful for studying squamous cell carcinoma (SCC).

These transgenic mice express human KLF4, Kruppel-like factor 4, under the direction of the tetracycline operator promoter (tetO). Following DOX induction, bitransgenic mice exhibit hyperkeratosis, atrophy of sebaceous glands, cystic degeneration of hair follicles and hyperplasia. This strain may be useful for studying squamous cell carcinoma (SCC).

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.