These transgenic mice express human GLI1, GLI1-Kruppel family member GLI1, under the direction of the tetracycline operator promoter (tetO). Mice hemizygous for the transgenic insert are viable and fertile. It is not known if homozygotes are viable. When mated to mice carrying K14-rtTA (also known as Tg(KRT14-rtTA)208Jek)), GLI1 expression is directed to skin cells and regulated with tetracycline or its analog doxycycline (DOX). Following DOX induction, bitransgenic mice exhibit dorsal hair loss and skin lesions characterized by nests of basaloid cells budding from the epidermis. This strain may be useful for studying cutaneous basal cell carcinoma (BCC).

These transgenic mice express human GLI1, GLI1-Kruppel family member GLI1, under the direction of the tetracycline operator promoter (tetO). Following DOX induction, bitransgenic mice exhibit dorsal hair loss and skin lesions characterized by nests of basaloid cells budding from the epidermis. This strain may be useful for studying cutaneous basal cell carcinoma (BCC).

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.