| Allele Name | targeted mutation 1, Frank J Slack |
| Allele Type | Targeted (Conditional ready (e.g. floxed), Inducible, Inserted expressed sequence, Transactivator) |
| Allele Synonym(s) | Gt(ROSA)26Sortm1(tetO-Mir155)Fjsl; mir-155LSLtTA |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | |
| Expressed Gene | tetO, tet operator, |
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| Expressed Gene | Mir155, microRNA 155, mouse, laboratory |
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| Site of Expression | When activated by Cre recombinase, miR-155 expression was evident in the spleen, thymus, and bone marrow. |
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| Strain of Origin | (C57BL/6J x SJL/J)F2 |
| Chromosome | 6 |
| Molecular Note | A construct was inserted into the locus that contained the following elements (5' to 3'): the tetracycline transactivator (tTA), two poly-adenylation sequences, the tetracycline operator with minimal CMV promoter, a floxed neo cassette with 4 poly-adenylation sequences, the mouse transcript, and a poly-adenylation sequence. The locus promoter drives expression of tTA while the tet operator drives expression of the transcript only after cre mediated removal of the floxed neo-STOP cassette that can be repressed by doxycycline treatment. |
