This congenic is part of a panel of nested congenics of Chromosome 11 sequence derived from A/J and bred onto C57BL/6J. They are useful for mapping traits that differ between A/J and C57BL/6J and map to Chromosome 11.
Judy Morgan, JAX
This congenic strain was generated as part of a study funded by The March of Dimes to elucidate the genetic basis of gestation length in mice. In particular, this series of nested congenics was created to look for A/J-derived sequence on Chromosome 11 that could modify the gestation length of C57BL/6J. This Chromosome 11 congenic has a gestation length that is not significantly different from C57BL/6J.
Several C57BL/6J-Chr 11A/J/NaJ female consomic mice, at approximate generation N13F20, were bred with C57BL/6J males and the F1 and F2 offspring were sibling intercrossed. Generation F3 breeders were selected with the aid of SNP marker genotyping to identify the material to produce a panel of nested intervals that vary by the sequence of A/J Chromosome 11 captured on a C57BL/6J background. Each congenic line was produced by successive generations of marker-assisted breeding to homozygosity for the congenic interval. The congenic interval for this strain, which was line B, includes A/J-derived sequence from Chromosome 11 rs3663879 through rs3023710. In 2013 sperm was cryopreserved from homozygous males at generation N1F11.
Currently there are no related genes or alleles for this strain.
When using the B6.A-(rs3663879-rs3023710)/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #018991 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous |
Frozen Mouse Embryo | B6.A-(rs3663879-rs3023710)/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.A-(rs3663879-rs3023710)/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.A-(rs3663879-rs3023710)/GrsrJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.A-(rs3663879-rs3023710)/GrsrJ Frozen Embryo | $3373.50 |
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