The Flk1::Cre "knock-in" allele has a Cre recombinase gene inserted into exon 1 of the kinase insert domain protein receptor (Kdr) gene, abolishing gene function and placing Cre expression under the control of the Kdr promoter/enhancer elements. KDR, also known as Flk1 or VEGFR2 (vascular endothelial growth factor receptor 2), is a type III receptor tyrosine kinase which mediates VEGF-induced regulation of angiogenesis, vascular development, vascular permeability, and embryonic haematopoiesis. Heterozygous mice are viable and fertile. The donating investigator reports Cre recombinase activity is observed in all embryonic and adult blood and vascular endothelial cells. When bred with mice containing loxP-flanked sequences, Cre-mediated recombination will result in deletion of the floxed sequences in the VEGFR2-expressing cells in the offspring.

These Flk1::Cre mice may be useful for generating conditional mutations for fate mapping blood and vascular endothelial cells.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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